The role of microbiota in pathogenesis and development of viral infections

Introduction and purpose
 The microbiota plays an important role in human metabolism, immune system, development of many chronic diseases, cancers, infectious diseases. aim the study is to present gut viral infections, including HBV, Herpesviridae, HIV, SARS-CoV-2. newest publications from last 5 years available on PubMed database were taken into account.
 A brief description state knowledge
 mechanism by which bacterias have impact infection based a synthesis specific short-chain fatty acids (SCFAs) modulation cytokine release system function bacterias. Domination Gardnerella vaginalis lack Lactobacillus vaginal microbiome increased risk HSV-2 women. Inflammation genital tract can influence susceptibility HIV infection, but probiotics via enhancement barrier integrity, change TH17/Treg ratio, restore composition. LPS - component structure Gram-negative bacteria be marker HBV infection. In airway patients with COVID-19 opportunistic microorganisms identified.
 Conclusions 
 Diet, intake probiotics, fecal transplantation (FMT) are interventions that might efficient methods prophylaxis treatment Further studies needed evaluate action pathogenesis